Analysis of antimicrobial effects of a contactless, indirect cold atmospheric plasma-aerosol method for germ reduction on surface: an in vitro and in vivo study.
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Focus

The study evaluated the microbiocidal efficacy of Cold Atmospheric Plasma-Aerosol (CAP-A) using PLASMO®HEAL. 
 

Findings

• In a vitro testing (DIN spec. 91315, against 5 pathogens showed reductions of 3.4–4.5 log levels (average 4.77)). 

• In vivo tests (EN 1500, on human skin using E. coli K12 showed reductions of a mean log reduction factor of 4.77, exceeding the 4-log threshold considered clinically relevant. Notably, CAP-A showed comparable efficacy to an alcohol-based reference disinfection method (p = 0.134), without associated drawbacks. 

Conclusion

CAP-A proved to be effective, safe, and residue-free, providing a viable non-contact alternative to conventional antiseptics with strong potential for wound care in particular in case of microbial colonization. 

New Approaches to Disinfection of Thermolabile Medical Devices Using an Indirect Method: Cold Atmospheric Plasma-Aerosol.
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Focus

The study investigated indirect Cold Atmospheric Plasma-Aerosol (CAP-A) using PLASMO®HEAL for effective and safe disinfection of thermolabile medical devices
- a transvaginal ultrasound probe was used as the reference product.  

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Findings

• It was showed that Enterococcus hirae (mean logarithmic reduction factor (LRF) > 6.23), Staphylococcus aureus (mean LRF > 6.51), and Enterococcus faecium (mean LRF > 6.16) demonstrated > 99.9999% in germ reduction.  

• For Pseudomonas aeruginosa (mean LRF > 5.40) and Escherichia coli (mean LRF > 5.29), a germ reduction of > 99.999% was achieved.  

• For Candida albicans (mean LRF > 4.95) and Clostridioides difficile (mean LRF > 4.62), a germ reduction of > 99.99% was demonstrated.  

• The log reduction demonstrated significant inactivation of the six tested microorganisms. Regarding highly tenacious microorganisms, such as Clostridioides difficile, CAP-A proved effective, superior to alcohol-based methods, and without the development of resistance.  

 

Perspectives

• CAP-A can be used to enhance solving a globally existing problem for the hygienic treatment of thermolabile medical devices.  

• Using the study as a surrogate 15 minutes of CAP-A using PLASMOHEAL seems to be able to sterilize contaminated skin. 

Study on hand disinfection in inpatient geriatric care on the superiority of cold plasma aerosol versus alcohol-based disinfection methods in a parallel group design. 
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Focus

To compared the disinfectant efficacy of Cold Atmospheric Plasma-Aerosol (CAP-A) using PLASMO®HAND in 8 seconds with alcoholic hand disinfectant for hand disinfection.  

 

Findings

The microbial count on participants’ hands was measured (nurses).  

Statistical analysis revealed that the mean log colony-forming unit (CFU) values were significantly lower using PLASMO®HAND compared to the cohort using conventional alcohol-based hand disinfection.  

 

Conclusion

• Unlike alcohol-based hand disinfection, CAP-A ensures effective elimination of Staph. aureus.  

• Staff utilizing CAP-A had an average bacterial count of 0.65 log units lower than those who use alcohol-based hand disinfection.  

• With the refillable water tank of PLASMO®HAND, approximately 2000 disinfection cycles can be carried out, which theoretically corresponds >15 plastic bottles with 500 ml of hand sanitizer each.  

• CAP-A disinfection enables a time saving - 8 s compared to 30 s for alcohol-based hand disinfection. 

Plasma disinfection procedures for surfaces in emergency service vehicles: a field trial at the German Red Cross.

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Focus

A demand for easy, harmless, automated, human independing disinfection within ambulances in order to reduce potential high risk of infections.  

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Findings

• An ambulance was contaminated deliberately by applying an Enterococcus faecium suspension on 8 spots followed by disinfection using Cold Atmospheric Plasma (CAP) delivered by PLASMO®CAR.  

• A reduction of 3.73 log levels in initial bacteria was accomplished within the rescue vehicle, eliminating up to 99.99% of the initial microorganisms.  

 

Conclusion
PLASMO®CAR is suited and convenient as a continous disinfection procedures creating asepsis on surfaces in the near field of the device, or inside a room. 

Case Report. Cold Atmospheric Plasma Treatment of Equine Dermatophytosis: A Novel Therapeutic Approach.  

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Focus

The treatment of dermatophytosis, a common fungal skin infection horse, using Cold Atmospheric Plasma-Aerosol (CAP-A) as a standalone treatment delivered byPLASMO®VET twice daily (each treatment session consisted of two 3-min fogging cycles on 12 consequtive days). 

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Findings

• Initial microbiological examination identified Trichophyton ssp. (Trichophyton mentagrophytes, Trichophyton benhamiae, Trichphyton erinacei, Trichophyton tonsurans, Trichophyton equinum, Trichophyton verrucosum, or Trichophyton rubrum) as the definitive aetiology.  

• Post-treatment samples were negative for all of the tested dermatophytes including Microsporum canis, and Nannizzia ssp. Clinical progression was documented using clinical photos.  

 

Conclusion

• No signs of discomfort during or after the treatment sessions was observed. 

• The therapy of CAP-A demonstrated promising results as a non-pharmacological treatment option for equine dermatophytosis, achieving both clinical and microbiological resolution without adverse effects.